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We investigate the role of mechanics in early brain development as part of CRC 1540 – Exploring Brain Mechanics.


Specifically, we study the interplay of mechanical factors and planar cell polarity (PCP) signaling in early nervous system development of Xenopus laevis. We’re developing organoids with tunable mechanical properties and extracellular matrix proteins to study brain morphogenesis (shaping), differentiation and patterning.

By manipulating mechanics, PCP signaling and analyzing various parameters, we aim to uncover the intriguing influence of mechanics on biochemical signaling in tissue specification and differentiation and tissue morphogenesis (i.e. acquiring its characteristic shape) of the early brain.


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